What is the difference between Klimadinon and Mastodinone? Klimadinon - instructions for use, composition, indications, side effects, analogues and price. Klimadinon UNO - instructions for use

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Almost every woman, having reached the age of 45-55, feels the symptoms of the menopause, which manifest themselves in connection with a decrease in the functions of sex hormones.

This process is natural.

But various climacteric syndromes, neuroses, disorders often cause such a serious condition that life turns into continuous torment.

Menopause changes

Age-related changes in the fairer sex are associated with a decrease in reproductive function. This period is accompanied by certain transformations in the systems of their body. Increased fatigue, irritability, lack of sleep, pain, changes in blood pressure, interruptions in the contraction of the heart, , muscle impotence, - symptoms that are known to most of the fairer sex.

In addition, at this time there is an exacerbation of existing ailments, new ones appear, mainly related to cardiovascular system increases the risk of developing osteoporosis.

To help a woman overcome this important period for her more calmly, doctors prescribe treatment using drugs that improve metabolism, as well as drugs or directions that are effective in relieving patients of menopausal manifestations.

Among them is the widely used Klimadinon, which belongs to phytoestrogens.

Phytoestrogenic therapy

- a powerful enough tool to get rid of menopausal symptoms. Often they are in no way inferior to hormonal drugs, which, as you know, are synthetically produced.

One of the advantages of phytoestrogens is their ability not to stimulate, but to suppress the development of hormone-dependent tumors. They do not have side effects, but, unfortunately, they are ineffective in severe pathologies of the climacteric syndrome.

You should not expect instant results from phytoestrogens. The action of such substances is gradual, as they accumulate in the body.

The result of their intake is not as noticeable as, say, in the treatment of synthetic hormones, but the negative impact and contraindications are much less.

They do, however, have a number of advantages.:

  • do not contribute to the formation of hormone-dependent neoplasms;
  • do not provoke explosions of the emotional state, but, on the contrary, have a positive effect on the nervous system;
  • thin blood viscosity, therefore, prevent thrombosis;
  • have a strengthening effect on the body's defenses;
  • allow better absorption of vitamins.

Description of the drug

It is to phytoestrogens that the drug Klimadinon belongs. This medicine is produced in Germany by the Bionorica company, which specializes in the manufacture of herbal remedies from plants grown on its plantations on the island of Mallorca.

Having a natural origin, this drug ensures its good tolerability, as well as the possibility of using it in combination with others. Treatment with Klimadinon improves metabolism in bone tissue and reduces its destruction..

Operating principle

Klimadinon, the main active ingredient of which is an extract from the roots of cimicifuga branched, significantly improves well-being during menopause in women, weakens its unpleasant manifestations. This is possible as a result of the interaction of the substances of this plant with estrogen receptors located in different parts of the female body.

It is this allelopathy that has a positive effect on overcoming menopausal failures and creating positive factors in overcoming the pathological manifestations of this period.

In patients taking Klimadinon, it is noted:

  • reduction or complete disappearance of "hot flashes", rapid or irregular heartbeat;
  • apathetic, depressive, nervous and aggressive states go away;
  • sleep becomes normal.

NOTE!

The main advantage of the drug is its safe effect on the endometrium, which makes it possible to use it as a preventive measure for the treatment of such a common female pathology as endometriosis.

Klimadinon goes well with replacement drugs hormone therapy and other medicines, provided that they do not contain cimicifuga substances. But its reception should always be agreed with the doctor, especially in the presence of pathologies associated with disorders of the cardiovascular, nervous and urogenital systems.

Indications

This drug is prescribed at, during and after it.

This usually happens in cases of:

  • neurovegetative disorders;
  • sudden sensations of heat;
  • indifference to everything
  • mood swings;
  • increased nervous excitability;
  • sweating.

The composition of the medicine

Klimadinon is produced in three types:

  • coated tablets of 20 mg;
  • coated tablets of 32.5 mg (Klimadinon UNO);
  • drops of alcohol solution.

In addition to the main active substance, the composition of the tablets includes 58% ethyl alcohol, lactose, as well as additional components that form their shell. The liquid form of the drug contains 35-40% ethyl alcohol, for this reason they are not prescribed to patients who like to drink, as there is a temptation to drink the whole bottle at once. Of course, this will not allow it to be cured, but health problems can only increase.

Contraindications

Despite its natural origin, Klimadinon should not be taken by everyone. This medicine is forbidden to prescribe to those who have a clear sensitivity to its main components.

You can't take it with:

  • not perceiving lactose;
  • with epileptic seizures;
  • liver and kidney failure;
  • pathologies of the brain;
  • injury;
  • when a woman is pregnant or breastfeeding;
  • susceptibility to allergies.

Dosage

The drug is usually taken 1 tablet in the morning and evening (UNO - 1 time per day). It is desirable that this be during meals and at the same time. Klimadinon in liquid form is prescribed 30 drops 2 times a day.

The doctor, based on the characteristics of the patient (for example, overweight or underweight), may increase or decrease the dose.

The therapeutic effect does not make itself felt immediately, but manifests itself, as a rule, after one and a half to two weeks.

The duration of the course of treatment with Klimadinon is determined by the doctor. Well, for those who want to take the medicine on their own, you need to know that it is not recommended to do this for more than 3 months.

Conclusion

Menopause is a difficult period for every woman. But it's not that hard to get over it now. After all, there are a number of drugs that alleviate their difficult condition, relieving unpleasant menopausal manifestations. The main thing is to choose the right and effective drug. So take care, dear ones, and be healthy!

Reviews

It should be noted that Klimadinon receives them mostly positive. In clinical practice, this drug is often used, especially in anticlimacteric therapy.

Most patients note the excellent tolerability of this medication, and only in some cases side effects are noted:

(( reviewsOverall )) / 5 Patient evaluation (16 votes)

Evaluation of a drug or treatment

The occurrence of mastopathy with menopause is a fairly common occurrence. After all, serious hormonal changes occur in a woman's body, which affect not only the genitals, but also other systems.

In addition, many women, due to their age, are afraid that problems with the mammary gland will cause the appearance of malignant tumors. Of course, the progression of the disease can be unpredictable.

But the main thing is to consult a doctor in time and undergo a full examination with further treatment of the disease.

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Causes

Mastopathy with menopause can occur for various reasons. The main one, of course, is considered to be hormonal changes and disruptions in the body.

But besides this, there are a number of other factors that provoke this disease in the menopause. Therefore, it is worth highlighting all possible reasons occurrence of mastitis.

These include:

  • hormonal changes in a woman's body;
  • transferred infectious diseases;
  • diseases accompanied by an inflammatory process in the genital organs;
  • frequent stress.

First of all, pathological changes are associated with sex steroid hormones and malfunctions. menstrual cycle. During menstruation, women release a hormone - progesterone, which ensures the functioning of the mammary glands.

With menopause, which is the most dangerous period for a woman's body, there is a lack of it. At the same time, the level of estrogen, on the contrary, increases, causing an imbalance.

Doctor's advice: even if menopause has not yet come, you should be very attentive to your health, and in particular to your chest. Indeed, after 40 years, the risk of mastopathy and other serious diseases in a woman's body increases significantly.

As a result of such fluctuations, the functioning of the mammary glands is disrupted, which subsequently leads to the growth of connective tissue. But also do not discount the transferred diseases of the genital organs. In the case of endometriosis or uterine fibroids, there are also cases of mastopathy.

Symptoms

Women's breasts under the influence of age factors tend to change. Changes are especially visible during menopause.

This is the body's response to ongoing hormonal changes. But if such a picture is accompanied by pain, it is necessary to pay special attention to this.

In addition to the fact that mastopathy is a rather serious problem, its development can provoke the occurrence of more life-threatening diseases. At the first stages of the disease, a woman feels aching.

Over time, with the growth of tissues in the mammary glands, small nodules form. Despite the fact that they are quite difficult to feel when palpated, painful sensations should be a signal to contact a specialist.

Indeed, in the first stages of mastopathy, the so-called in medical practice, the pathology can be easily eliminated with the help of special methods of treatment. The second stage of development of mastopathy is more serious.

Small nodules in the mammary gland form seals that increase significantly, sometimes reaching the size walnut. But the main thing is the development of such seals into malignant tumors. In such cases, the disease is already qualified as an oncological disease.

Annoying factors

In addition to the main causes of mastopathy, doctors identify several irritating factors that can cause the development of this disease during menopause.

These include:

  • heredity;
  • a large number of abortions or miscarriages;
  • frequent pregnancies;
  • excess weight;
  • diabetes;
  • refusal to breastfeed;
  • pregnancy after 30 years.

Women who have experienced similar situations are at risk. Therefore, experts recommend that they regularly undergo a complete examination in a hospital.

Since mastopathy is a benign disease only at the first stage of its development. Therefore, the earlier the disease is diagnosed, the easier it will be to eliminate it.

Treatment

I would like to note right away that never self-medicate and do not use folk remedies without prior consultation with a physician.

This can significantly aggravate the situation, provoking the occurrence of more serious complications. To effectively eliminate this problem, doctors conduct a complete examination of the patient.

During the diagnosis, a woman must take a blood test, which makes it possible to assess the hormonal background and identify all possible deviations. If there are hormonal fluctuations, specialists prescribe certain hormonal drugs.

In the postmenopausal period, hormonal drugs are less effective. Therefore, doctors use gestagenic agents.

They are drugs to normalize the hormonal balance in the body, eliminating excess estrogen. The most common representatives of this group are: Dufaston, Progesterone or Utrozhestan.

Take note: to reduce the risk of mastopathy during menopause, you need to monitor your breasts, adhering to the basic rules. The essence of these recommendations lies in properly selected underwear, healthy eating and constant monitoring of the mammary glands.

Due to the fact that during menopause women experience hot flashes, she feels constant fatigue, irritability and nervousness, some experts prescribe homeopathic remedies. The use of such drugs makes it possible to save the patient from menopausal symptoms, improving the general condition.

In addition, the funds help reduce pain in the chest and armpits, normalize hormonal levels, relieve tissue swelling, and also strengthen the immune system. In case of violation of the psycho-emotional state and the main symptoms of mastopathy, doctors prescribe drugs such as: Klimaksan, Klimadinon or.

An auxiliary method for eliminating mastopathy during menopause is vitamin therapy. Replenishment of the body essential vitamins improves the functioning of the whole organism and accelerates the healing process.

In more severe cases, a woman may need surgery. It is carried out most often if general therapy does not give positive results, or there is a risk of more serious diseases in the body.

For the treatment of mastopathy with menopause, see the following video:

Mastopathy with menopause is dangerous, as in other cases. Therefore, its treatment must be taken with all responsibility. At the first symptoms, you need to undergo a comprehensive examination by a specialist. The mammary glands are very sensitive to any changes in hormone levels, so mastopathy can occur during menopause.

Why do breasts suffer during menopause?

The cessation of menstruation and other changes in a woman's body occur after forty years. During this period begins hormonal changes organism, which can bring out many diseases that a woman had not thought about before. The structure of the breast may also change. The connective tissue begins to grow and mastopathy develops.

In addition to hormonal changes, everything that happened to a woman's reproductive system before menopause contributes to the disease:

  • Early onset of menses. In this case, the volume of female hormones increases before the development of the mammary gland occurs. Years later, against the background of this, mastopathy may occur.

  • Venereal diseases, especially if they have not been fully cured and become chronic.
  • Inflammatory processes in the organs of the reproductive system.
  • Late pregnancy or its absence, refusal to breastfeed or a short period of feeding, artificial suppression of lactation. If a woman breastfeeds for less than six months, then the mammary glands do not have time to completely rebuild, which can subsequently cause mastopathy.
  • Artificial termination of pregnancy becomes stressful for the body, because it causes a sharp restructuring of hormones.
  • Failure to comply with the rules for taking oral contraceptives.

Mastopathy can also occur against the background of constant tension, stress, overwork and environmental factors.

During menopause, metabolism is often disturbed. This can lead to obesity, which negatively affects the functioning of the thyroid gland, which is why the balance of hormones is disturbed.

Menopause is characterized by a fibrocystic form of mastopathy. Its signs can significantly impair the quality of life, but the main danger lies in the possibility of degeneration into cancer.

How to identify pathology

Symptoms of mastopathy during menopause often do not appear, or against the background of menopause, a woman simply does not notice the manifestations of the disease. This contributes to the fact that the disease is detected late, when the risk of complications is already quite high. In order to determine the pathology in time, it is necessary to visit a mammologist regularly.

Mastopathy may have the following symptoms:

  • Since menstruation stops during menopause, a woman does not feel the usual signs of illness, such as breast tightness and soreness during PMS. Therefore, a woman may notice the first symptom during self-examination of the breast. Feeling small seals or nodules, you should immediately consult a doctor.
  • Gradually, a feeling of heaviness may occur in the mammary gland. This is due to the fact that the connective tissue swells, clogs the milk ducts and puts pressure on the nerve endings.

  • Sometimes there may be pain, but it is intermittent. Unpleasant sensations occur when pressing on the seal.
  • Pain in the mammary gland may be accompanied by headache, anxiety, swelling of the chest, a strong sense of fear.
  • During menopause, if a woman has mastopathy, milk may begin to flow from the nipples. There are usually few discharges, but if they occur, it is necessary to conduct a comprehensive examination for other pathologies.
  • In rare cases, the nipples may darken and the breasts may enlarge.

If the body temperature rises during mastopathy, then it is necessary to be examined for the presence of infections in the gland.

Mastopathy with menopause should not be ignored, as it increases the chances of developing cancer. Signs of the disease need to be known in order to conduct a timely diagnosis. The danger is nodular mastopathy, diffuse usually does not develop into cancer.

Features of the treatment of the disease

Treatment of mastopathy with menopause is prescribed only after a gynecological examination, examination for hormone levels and other diagnostic measures.

After the diagnosis is made, the method of treatment is determined. Apply drug and non-drug therapy. The first is designed to establish hormonal balance, and the second is for the radical removal of neoplasms.

It is also necessary to normalize metabolic processes, strengthen immunity, adjust nutrition and lifestyle. It is advisable to follow a diet that excludes caffeine, cocoa, chocolate, tea, cola. Also, doctors recommend eating foods rich in fiber and drinking enough fluids. Vitamin B6 is prescribed to improve the functioning of the liver.

Hormonal remedies

If the pathology is found at the beginning of menopause, when menstruation has not yet stopped, the woman is prescribed oral contraceptives. This treatment is necessary for an imbalance of sex hormones. Use drugs such as Regulon, Jeanine, Novinet.

After the cessation of menstruation, such therapy will not give the desired effect. Mastopathy often occurs due to high levels of estrogen. In this case, it is necessary to reduce their effect on the mammary glands. For this, gestagens Duphaston, Utrozhestan and others are prescribed.

To eliminate the influence of estrogen, drugs containing male sex hormones can be used.

At high level prolactin is prescribed by its inhibitors.

Medicines containing hormones should be used only after consultation with a specialist. The doctor must accurately select the type of medication and dosage. Incorrectly selected treatment can not only not bring benefits, but also cause irreparable harm to health.

Herbal preparations

Before prescribing herbal preparations for the treatment of pathology, the doctor must find out how a woman manifests menopause. Only taking into account the headache, insomnia, nervousness, hot flashes and other symptoms, treatment is prescribed. Some experts even prefer to use homeopathy instead of hormonal treatment, as it can be dangerous to use hormonal drugs.
Mastodinon and Klimadinon are popular.

These drugs allow you to establish a hormonal balance, reduce the symptoms of menopause, mastopathy, strengthen the immune system, fight swelling. It is very important that after using these agents, tissue growth does not increase. Also, due to the natural composition, they do not harm the body.

Vitamin complexes

Treatment of mastopathy in any period is not complete without the use of vitamins. Vitamins A, C, E and group B are used to stabilize metabolism, establish hormonal balance, and normalize the functioning of the nervous system. But it must be borne in mind that the abuse of vitamins can lead to an increase in the symptoms of the disease.

Sedative drugs

Stress only worsens the woman's well-being and the course of the disease, therefore, drugs are used to normalize the psycho-emotional state.

Calming effects have drugs based on medicinal plants such as valerian, motherwort and others. If they do not give the desired result, strong sedatives are prescribed.

Surgery

If specialists detect the occurrence of malignant cells, then an operation is prescribed. Usually, surgical treatment is used for nodular mastopathy. Depending on the location of the neoplasms and the rate of progression of the disease, they can remove the tumor with part of the gland or the entire breast.

In combination with traditional methods can be used folk recipes. This treatment is quite common. But you need to do this carefully and under the supervision of a doctor, otherwise the effect will be less than harm.

If mastopathy occurred during menopause, this is not a sentence. Of course, when combined with menopausal symptoms, this is quite unpleasant, but there are treatment options. The main thing is to detect the pathology in time and get rid of it before the malignant process begins. To do this, you need to regularly visit a doctor and monitor your health.

With age and the advent of menopause, the risk of breast cancer increases. Mastopathy with menopause requires serious attention from the woman and the doctor: with any form of FKM, it is necessary to conduct a regular examination and follow the medical recommendations of a specialist. Mandatory instrumental examination is mammography at least once every 2 years.

Possible options for pathology

A common variant of breast pathology in older women is fibrous mastopathy where the risk of complications is minimal. Against the background of menopause, the negative impact of hormonal disorders associated with hyperestrogenism decreases, so there are no proliferative processes in cells. Age-related involution leads to the replacement of glandular tissue with fibrous and adipose tissue. Mastopathy during menopause is manifested by the following diseases:

  • diffuse pathology with fibrosis of breast tissue;
  • fibrocystic variant of the disease;
  • nodal form of FCM;
  • mammary cancer.

In menopause, you should be very careful about breast health: after 50 years, the risk of oncological pathology increases, so all women should visit the doctor regularly. Preventive medical examinations are especially important in the presence of a family predisposition and a proven genetic risk.

Causes of the disease

The standard age for menopause is 45–55 years. During this period of time in female body there are numerous metabolic and endocrine changes due to the cessation of the ovaries. The main causative factors of mastopathy after menopause:

  • a sharp decrease in the influence of estrogen hormones;
  • almost complete cessation of the antiproliferative effects of Progesterone;
  • change in the ratio of pituitary hormones (FSH, LH);
  • deposition of fat in the mammary glands;
  • proliferation of connective tissue in the breast (fibrosis).

Of great importance for the formation of fibrosis and diffuse changes in the breast are the following provoking factors:

  • female diseases (uterine leiomyoma, endometrioid disease);
  • refusal to bear children;
  • frequent abortions with complications and inflammatory processes;
  • general metabolic and endocrine diseases (diabetes, metabolic syndrome, thyroid disease);
  • prolonged psychological stress or stress.

The most important factor in the disease is genetically programmed heredity: if a woman has relatives with mastopathy or breast cancer, then it is necessary to constantly monitor the condition of the glandular tissue and conduct annual preventive examinations with a mammologist.

Symptoms of the disease

In the early stages of the disease, a woman may have no external manifestations or there may be slight soreness in the chest. As FCM progresses, the following symptoms appear:

  • local pain or general heaviness in the mammary gland;
  • a formation in the chest detected by palpation;
  • galactorrhea (discharge from the nipples), which is not always;
  • changes on the skin and in the area of ​​the areola.

A typical reason for visiting a doctor is the discovery of a node or a tumor-like neoplasm. It is important to consider the location of the pain: often a woman cannot separate cardiac pain from mastopathy on the left. Extremely unpleasant symptoms are nipple deformity and detection of skin changes like lemon peel. An experienced mammologist will evaluate all complaints, make a preliminary diagnosis and refer you for examination.

Diagnostics

In addition to the standard palpation examination, the following studies must be performed:

  • x-ray mammography in three projections;
  • assessment of hormonal status;
  • blood tests for tumor markers;
  • computed tomography with contrast.

Ultrasound diagnostics in women over 35 years of age is not informative: fibro-fatty changes will interfere with the visualization of pathological structures of the breast. However, if puncture biopsy of nodular neoplasms is necessary, ultrasound can and should be used.

The only accurate and reliable method for excluding breast cancer is a histological examination of a biopsy specimen taken from a focus of mastopathy. The diagnostic technique is used according to strict indications and as prescribed by a mammologist.

Medical tactics

Identified mastopathy in menopause, the treatment of which can be conservative or surgical, requires long-term observation by a doctor. The absence of a risk of oncopathology is not a reason for refusing an annual visit to a mammologist: tumor changes in the breast tissue can come as a surprise to a woman and a doctor.

Medical therapy

Drug treatment diffuse mastopathy in menopause selected with the obligatory consideration of menopausal symptoms. The doctor may prescribe non-hormonal drugs plant origin, which will have a positive effect on the general condition and manifestations of FCM. Diet therapy is of great importance: it is necessary to eat foods recommended by a specialist. From medicines it is necessary to drink vitamin-mineral complexes and sedatives.

Surgical intervention

The operation is performed according to indications, which include:

  • nodular mastopathy;
  • detection of a large cystic cavity in the mammary gland;
  • detection of proliferation in cells obtained by aspiration biopsy;
  • suspicion of malignant degeneration of a benign tumor.

In each case, the mammologist, based on the results of diagnostic studies, chooses the extent of the operation individually. In the postoperative period, a course of rehabilitation and long-term observation by a doctor will be required.

Forecast for life

With age, the risk of detecting a malignant tumor increases, so FCM during menopause is a risk factor for oncopathology. It is categorically unacceptable to ignore preventive visits to the doctor or use folk remedies for self-treatment. With timely detection and treatment of benign breast pathology, the risk of degeneration is minimal, and the prognosis for life is favorable.


10.03.2013

Hormone Replacement Therapy (HRT) natural estrogens in combination with progestogens are now increasingly used to treat estrogen deficiency syndrome caused by natural or artificial menopause. At the same time, long-term use of estrogen-progestin drugs as hormone replacement therapy, in addition to positive changes in homeostasis, also has undesirable side effects (impaired liver function and hemocoagulation system, cyclic hemorrhage in postmenopause), which are observed in 15-25% of cases and often lead to the abolition of replacement hormone therapy.

Of no small importance is the risk of induction of a tumor disease in patients with a burdened oncological heredity, which often does not allow hormone replacement therapy to be carried out for a long time, which is necessary to achieve a full clinical effect.

In this clinical situation, it seems promising the use of herbal medicines, derived from plant materials and possessing estrogenic activity. For example, klimadinon containing phytoestrogens isolated from the root of cimicifuga. To date, from a large number of such compounds, three main groups have been isolated and studied: lignans, isoflavonoids, and diphenolic phytoestrogens.

A feature of these compounds is a fairly pronounced estrogen effect on the hypothalamic-pituitary complex and a weak effect on peripheral target tissues. Moreover, under certain conditions (preferential binding to estrogen b-receptors in target tissues), the antiestrogenic effect of phytoestrogens is possible, which creates safe conditions for their use in patients with a history of hormone-dependent tumors.

Another remedy from the group of phytopreparations that have an effect on the hypothalamic-pituitary system as a dopaminomimetic is mastodinone containing alcoholic extracts of Agnus castus and other alkaloid plants; it is widely used in gynecological endocrinology, in pathological conditions caused by a weakening of the influence of dopamine on the adenohypophysis and, as a result, hyperprolactinemia, menstrual disorders and infertility (prolonged state of anovulation).

Trial medicinal properties climadinone was performed in 56 patients ( average age 49.9 ± 1.8 years), who suffered from vegetative-vascular disorders and menstrual rhythm disturbances characteristic of menopausal syndrome. Of the 56 women, 27 were premenopausal and 29 postmenopausal (postmenopausal no more than 5 years).

The therapeutic effect of climadinone was evaluated by its effect on the elimination of a complex of vegetovascular disorders and the normalization of the rhythm of the menstrual cycle.

Before the appointment of both climadinone and mastodinone, all patients were examined at the center according to the adopted program, which includes primary gynecological examination, cytological examination, ultrasound of the small pelvis, examination and ultrasound of the mammary glands. According to the indications, a cytological examination of the endometrial aspirate or a biopsy of the uterine cavity mucosa was performed to exclude a tumor disease of the endometrium.

By the time of the start of treatment with both climadinone and mastodinone, the patients did not receive any additional drugs, if they were used earlier, they were canceled two weeks before the start of climadinone. Klimadinon was prescribed in drops, at a dose of 30 drops twice a day, or in a pill, 1 pill (20 mg of dry extract of cimicifuga rhizome) twice a day for three months.

The scheme of taking the drug was slightly changed by us: mastodynon was taken from 1-5 days of the new cycle (so that the effect of the drug began already during the formation of the first cycle), at a dose of 30 drops three times a day, inside, for three months without interruption. A repeated hormonal examination was carried out while taking the drug on the 18-24th day of the cycle, on the third month of treatment.

The testing of the medicinal properties of mastodinone was carried out in 39 patients (mean age 34.6 years) with various menstrual irregularities.

Conclusions on the results of clinical testing of climadinone and mastodin, carried out in 56 patients suffering from various manifestations of the climacteric syndrome:

  • Klimadinon is an effective phytoestrogen drug that causes relief of vegetative-vascular disorders in climacteric syndrome in 71.6% of patients by the fourth week of treatment.
  • The maximum therapeutic effect of climadinone develops by the fourth week of treatment, and the effectiveness of the drug is slightly higher in postmenopausal patients compared to premenopausal patients.
  • In patients in pre- and perimenopause, a three-month course of treatment with klimadinon led to the restoration of the correct rhythm of the menstrual cycle in 63% of cases. In women older than 50 years, prolonged amenorrhea occurred (38.5%).
  • Mastodinone is an effective phytopreparation prescribed to normalize the rhythm of the menstrual cycle at a dose of 30 drops three times a day, starting from the first or third day of the next menstrual cycle for three months. The maximum effect of mastodinone develops by the end of the third month of treatment (76.9% of cases).
  • The ability of mastodinone to significantly reduce the increased secretion of prolactin by the end of the third month of treatment indicates its "central", stimulating effect on the dopamine receptors of the adenohypophysis and hypothalamus, which leads to the implementation of the prolactin-inhibiting effect of the drug.
  • Under the influence of mastodinone, there is an increase in the cyclic secretion of LH and progesterone in the second phase of the menstrual cycle, which may indicate the restoration of ovulation and the development of a full-fledged luteal phase of the menstrual cycle. The latter can be considered as favorable condition for conception and pregnancy.